Y-27632
It is a selective and potent inhibitor of ROCK (Rho-associated coiled-coil forming kinase/Rho binding kinase).Y-27632 has a variety of activities including vascular smooth muscle contraction through the ROCK signaling (Ki = 140 nmol/L p160ROCK). This product has been reported to suppress death of human ES cells and human iPS cells at the time of cell dispersion, and also improves viability of the cells after cryopreservation.
- Y-27632 product grade
- Reference data of preparation
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Y-27632 product grade
We provide four grades of Y-27632 products. You can select according to the purpose of uses.
| ICHQ7 | Mycoplasma | Endotoxin | Viable bacteria |
Sterility | Animal- derived-free |
powder/ liquid |
References* | |
|---|---|---|---|---|---|---|---|---|
| Y-27632 (GMP grade is coming soon) |  |
|
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|
– | |
powder | – |
| Y-27632, MF** | – | |
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– | |
powder | |
| CultureSure® Y-27632 | – | |
|
– | – | |
powder | |
| CultureSure® 10mmol/L Y-27632 Solution, Animal-derived-free |
– | |
|
– | |
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liquid Sterilized with filter |
* Click to move to the PubMed Central® search results.
** We have a validation from the production to analysis and manage any changes for consistent, stable and high-quality production.
Reference data of preparation
The powder Y-27632 product has been confirmed to be soluble in water. After dilution, filter sterilize before use. Refer to the protocol at the top of this page for general usage in ES/iPS cell culture.
Amount of solvent when preparing solution
| Y-27632 (powder) | ||||
|---|---|---|---|---|
| 1 mg | 5 mg | 10 mg | ||
| Concentration | 1 mmol/L | 2.956 mL | 14.781 mL | 29.562 mL |
| 5 mmol/L | 0.591 mL | 2.956 mL | 5.912 mL | |
| 10 mmol/L | 0.296 mL | 1.478 mL | 2.956 mL | |
| 50 mmol/L | 0.059 mL | 0.296 mL | 0.591 mL | |
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Products listed in the protocol
Cytokine solutions
Related Information
Category
- Cell Culture
- Stem Cell Culture
- Undifferentiated State Maintenance / Differentiation Induction
- Small Molecules for ES/iPS cells Research
- CultureSure® Small Molecules
- StemSure® hPSC MediumΔ
For research use or further manufacturing use only. Not for use in diagnostic procedures.
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