anti-Asc，pAb (AL177)
凋亡相关斑点样蛋白 Asc 检测及功能抗体
Asc 促进半胱天冬酶介导的细胞凋亡。这种促凋亡活性主要通过半胱天冬酶-9 的活性介导。它是炎症小体的一个组成部分，炎症小体是包含 NLRP3/NALP3、CARD8 和 CASP1 的蛋白复合体，其功能是激活促炎性半胱氨酸蛋白酶。
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产品详情 |
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别名 |
Pycard、甲基化诱导沉默的靶点1、TMS1、Caspase Recruitment Domain-containing Protein 5、 细胞凋亡相关Speck样蛋白 CARD、CARD5 |
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产品类型 |
多克隆抗体 |
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免疫动物/宿主 |
兔 |
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免疫原/抗原 |
对应于 N 末端人 Asc 的氨基酸合成肽. |
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应用 |
免疫细胞化学（1：200） |
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交叉反应性 |
人、小鼠 |
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特异性 |
识别人和小鼠 Asc. |
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纯度 |
表位亲和纯化 |
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浓度 |
1 mg/mL |
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配方 |
液体，溶解在含有 10％ 甘油和 0.02％ 叠氮钠的 PBS 中 |
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运输 |
干冰 |
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短时间储存 |
+4°C |
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长时间储存 |
-20°C |
参考文献
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[1] |
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder: L. Agostini,et al.; Immunity 20, 319 (2004) |
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[2] |
P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1beta in Mouse Macrophage: P. Pelegrin, et al.; J. Immunol. 180, 7147 (2008) |
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[3] |
Inflammatory role of ASC in antigen-induced arthritis is independent of caspase-1, NALP-3, and IPAF: L. Kolly, et al.; J. Immunol. 183, 4003 (2009) |
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[4] |
Activation of autophagy by inflammatory signals limits IL-1b production by targeting ubiquitinatedinflammasomes for destruction: C.-S. Shi, et al.; Nat. Immunol. 13, 255 (2012) |
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[5] |
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice: M.T. Heneka, et al.; Nature 493, 674 (2013) |
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[6] |
Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation: J.K. Dowling, et al.; J. Biol. Chem. 289, 6429 (2014) |
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[7] |
Localization and functionality of the inflammasome in neutrophils: M. Bakele, et al.; J. Biol. Chem. 289, 5320 (2014) |
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[8] |
The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation: B.S. Franklin, et al.; Nat. Immunol. 15, 727 (2014) |
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[9] |
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response: A. Baroja-Mazo, et al.; Nat. Immunol. 15, 738 (2014) |
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[10] |
Aging-associated TNF production primes inflammasome activation and Nlrp3-related metabolic disturbances: F. Bauernfeind, et al.; J. Immunol. 197, 2900 (2016) |
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[11] |
An Investigation of Inflammatory and Metabolic Blood-Based Biomarkers of Cognitive Decline: H. Wolfe; Thesis Univ. Dublin, Trinity College Dep. of Physiol. (2018) |