IL-33（释放于坏死细胞）动员杀伤性Ｔ细胞应对病毒感染
◆原理
细胞死亡后会释放一类特殊的蛋白质 Alarmin（暂译为警报素），通过检测 Alarmin 可识别组织创伤。然而在抗病毒免疫系统中，Alarmin 所起的作用不是很明确。最近瑞士日内瓦大学和德国柏林夏里特医科大学研究人员发现在脾脏和淋巴结中病毒的复制可导致受感染的细胞死亡。这些坏死的细胞可释放出 Alarmin，其中主要的是白介素-33（IL-33），它可通过 ST2 受体激活 CD8+ T（CTLs）细胞，对病毒感染作出反应。研究发现缺乏 IL-33 的小鼠，CTL 对病毒感染的免疫反应也较低。此项研究具有里程碑意义，因为提出了一个新的免疫机制：坏死细胞会释放出 Alarmin 动员杀伤性Ｔ细胞应对感染，在未来对抗艾滋、丙型肝炎而开发新的疫苗，对于癌症治疗有重要作用。
Enzo Life Sciences 提供大量细胞坏死研究用产品，先天性免疫适应性免疫等。许多与 Alarmin IL-33 有关，供科研人员选择。
◆优点・特色
|
产品名称 |
特点 |
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IL-33 (human), ELISA kit |
Reliably measure as little as 1.7 pg/mL of IL-33 |
|
IL-33 (mouse) ELISA Kit |
Reliably measure as little as 10pg/mL of IL-33 |
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IL-33 soluble (human), detection set |
Reliably measure as little as 5pg/mL of IL-33 |
|
GFP-Certified™ Apoptosis/Necrosis detection kit |
Cell-based assay for microscopy and flow cytometry |
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IL-33 (human), (recombinant) |
≥95% pure (SDS-PAGE) |
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IL-33 (human), (recombinant) |
≥95% pure (SDS-PAGE), FLAG-tag |
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IL-33 (human), (recombinant) |
≥95% pure (SDS-PAGE), His-tag |
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Pro-IL-33 (human), (recombinant) |
≥90% pure (SDS-PAGE), His-tag |
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IL-33 (human) (homeodomain-like helix-turn-helix), (recombinant) |
Human IL-33 homeodomain, fused at C- terminus to His-tag, ≥95% pure (SDS-PAGE) |
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IL-33 (mouse), (recombinant) |
≥95% pure (SDS-PAGE) |
|
IL-33 (mouse), (recombinant) |
≥95% pure (SDS-PAGE), His-tag |
|
IL-33 (rat), (recombinant) |
≥95% pure (SDS-PAGE) |
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IL-33 (human), mAb |
Suitable for ELISA, IHC, IP, WB (clone IL33305B) |
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IL-33 (human), pAb |
Suitable for ELISA, WB |
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IL-33 (human), pAb |
Suitable for ELISA, WB, Biotin conjugate |
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IL-33 (mouse), pAb |
Suitable for ELISA, WB |
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IL-33, mAb |
Recognizes human and mouse IL-33. ELISA, IP, WB.(clone IL33026B) |
|
IL-33, mAb |
Recognizes human IL-33. Weakly cross-reacts with mouse IL-33. ELISA, WB. (clone IL33068A) |
|
IL-33, mAb |
Recognizes human, mouse and rat pro-IL-33 (precursor) and mature IL-33. ELISA, IHC, IHC, IP, WB (clone Nessy-1) |
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IL-33, mAb |
Biotin-conjugate (clone Nessy-1) |
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IL-33, mAb |
Preservative free, (clone Nessy-1) |
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IL-33, mAb |
ICC, WB (clone Nessy-2) |
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IL-33, pAb (AT110) |
Recognizes human, mouse and rat pro-IL-33 and mature IL-33, ELISA, WB |
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IL-33, pAb (AT110) |
Biotin-conjugate |
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ST2 (human), (recombinant) |
≥90% pure (SDS-PAGE) |
|
ST2 (human), mAb |
ELISA, IHC, IHC, WB (clone ST33868) |
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ST2 (human):Fc (human), (recombinant) |
≥90% pure (SDS-PAGE) |
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ST2 (mouse):Fc (human), (recombinant) |
≥95% pure (SDS-PAGE) |
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IL-1RAcP (human):Fc (human) (recombinant) |
Forms heterodimer complex with ST2 to make the IL-33 receptor. ≥95% pure (SDS-PAGE) |