Wako代理 028-17811 BES-H2O2-Ac 过氧化氢特异性荧光探针

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Wako代理 028-17811 BES-H2O2-Ac 过氧化氢特异性荧光探针

This product is for research use only. Do not administer it to human.

When deacetylated within the cell by esterase, this deacetylated product (see the reaction below) reacts with hydrogen peroxide by fluorescing. As such, it is ideal as a fluorescent indicator of intracellular hydrogen peroxide. This product reacts with hydrogen peroxide more specifically compared to other fluorescent indicators on the market.

[Advantages]

  • Selectively reacts with hydrogen peroxide
  • Membrane permeability
  • Enables monitoring of intracellular hydrogen peroxide

This product is for research use only. Do not administer it to human.

Highly Selective Fluorescent Probe for Hydrogen Peroxide

[Features]

  1. Highly selectivity toward H2O2
  2. Permeable to cell membrane
  3. Detectability of cell-derived H2O2
  4. Applicable to Molecular Imaging

Reactive oxygen species (ROS) such as superoxide (O2-.),hydrogen peroxide (H2O2), and the hydroxyl radical (HO.) are important mediators of pathological processes in various diseases. 2′,7′-Dichlorofluorescein (DCFH) and its diacetyl derivative have been widely used as fluorescent probes for measuring cell-derived H2O2, but these compounds suffer from the major drawback that they are poorly selective toward H2O2.BES-H2O2 is a probe for cell-derived H2O2 with high selectively. It is applicable to clarifying cell response as well as dynamic function of H2O2 with diseases.

Solubility: Soluble in DMSO, DMF and acetonitrileFluorescence:

  • excitation wavelength: 485 ± 20 nm
  • emission wavelength: 515 ± 20 nm

[References]

  1. Maeda, H., Fukuyasu, Y., Yoshida, S., Fukuda, M. Saeki, K.. Matsuno, H., Yamauchi, Y., Yoshida, K., Hirata, K. and Miyamoto, K. : Angew. Chem. Int. Ed., 43, 239 (2004).
  2. Maeda, H., Matsuura, S., Nishida, M., Senba, T., Yamauchi, Y. and Ohmori, H.: Chem. Pharm. Bull., 49, 294 (2001).

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Highly Selective Fluorescent Probes for Hydrogen Peroxide

BES H2O2 (cell-impermeant)(Wako Cat. #021-16201 (1 mg))

BES H2O2-Ac (cell-permeant)(Wako Cat. #028-17811 (1 mg))

[Fluorescence] excitation wavelength: 485 nm; emission wavelength: 515 nm
LINKProduct Page [BES-H2O2-Ac / BES-H2O2]

LINK  Catalog [Neuroscience Research 2018]