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Rev.081024 |
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| Suitable for immunohistocheistry. For research use only. |
| Acrolein (ACR) is a representative carcinogenic aldehyde found ubiquitously in the environment and formed endogenously through oxidation reactions, such as lipid peroxidation and myeloperoxidasecatalyzed amino acid oxidation. ACR is highly reactive aldehyde and reacts with lysine residue in protein. The reaction with ACR and lysine residue leads to the formation of numerous numbers of adducts, such as formyl-dehydropiperidino-lysine (FDP-lysine) type derivative. This antibody is specific for the ACR-modified protein, especially FDP-lysine type derivative. |
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| Specifications |
| Clone #: |
5F6 |
| Antigen: |
ACR-modified keyhole-lympet hemocyanine |
| Form: |
Frozen (100 µg/mL antibody in 10mM PBS containing 0.1% NaN3 and 0.5% BSA). Purified by Protein-A. |
| Application: |
Immunohistochemistry.
Recommended antibody concentration is 0.5-1.0 µg/mL on paraformaldehyde fixed tissue. |
| Specificity: |
Specific for ACR-modified protein (especially FDP-lysine type derivative) |
| Subclass: |
Mouse IgG1,kappa |
| Storage: |
Less than -20°C |
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| References |
| 1) |
Protein-bound acrolein: Potential markers for oxidativestress. K.Uchida, M.Kanematsu, K.Sakai, T.Matsuda, N.Hattori,Y.Mizuno, D.Suzuki,T.Miyata, N.Noguchi, E.Niki,T.Osawa
Proc.Natl.Acad.Sci.USA,95,4882-4887(1998) |
| 2) |
Protein-bound acrolein: A novel markers of oxidativestress in Alzheimer’s Disease. Noel Y. Calingasan, Koji Uchida, and Gary E.Gibson
Journal of Neurochemistry.72(2),751-756(1999) |
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| Product name |
Code |
Content |
| Anti Acrolein monoclonal antibody |
MAR-020n |
20 µg of IgG |
| MAR-100n |
100 µg of IgG |
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Manufactured by NOF corporation, Japan.
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If you are in the U.S., please click here
to Genox Corporation (Los Angeles, CA).
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| Instruction manual (PDF) |
Technical information |
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| [NOTICE]: Our products are for RESEARCH USE ONLY. Not for diagnostic, medical or other use.
We are making efforts to prevent errors or mistakes on preparing web site documents, instruction manuals and products.
But even if some damage would causedby such faults, we will be exempt from responsibility. |
日本衰老控制研究所 Japan Institute For the Control of Aging (JaICA) 专注于衰老研究领域。提供DNA氧化损伤检测试剂盒，并且处于该领域的领先地位。JaICA氧化应激相关产品：DNA氧化损伤检测、脂质氧化检测、蛋白氧化检测、抗氧化分析，以及微量元素分析。详情请咨询JaICA中国区代理商：上海金畔生物科技有限公司。
